Abstract

Background: A review of renal biopsy data gives insight into the spectrum of clinically significant renal
disease and necessary epidemiological data on renal diseases. Objectives: to analyze the
histopathological spectrum of native kidney biopsies in the north Karnataka population.
Material & Methods: A total of 772 patients who underwent kidney biopsies at Department of
Nephrology KIMS Hubli from January 2000 to December 2020 were included in the study. Results: The
mean age of patients was 36.77+25.15 years. The most common histopathological diagnosis made was of
primary glomerular disease (57.77%), followed by Tubulo-interstitial disease(17.61%), while the least
common was the vascular disease (1.8%). Glomereular disease is the most common histopathological
finding among renal biopsies. Among primary glomerular diseases Minimal change disease was the most
common finding noted in 23.31% of cases followed by Focal segmental glomerulosclerosis(18.16%),IgA
nephropathy (14.57%),Membranous GN(11.88%), Membrano proliferative GN(10.98%),
Mesangiocapillary GN (10.76%),Complement mediated GN (5.1%), Crescentic GN21 (4.7%), IgM
nephropathy (0.4%)was the least common finding among glomerular diseases.
Conclusion: a wide variation of major histological groups in the primary glomerular diseases has been
observed with most common being minimal change disease. However, among most countries of tHE
world, the most common secondary glomerular disease has been documented as LN.