European Journal of Molecular & Clinical Medicine

Abstract

Background: Thyroid dysfunction with metabolic syndrome is recognized risk of atherosclerotic and cardiovascular disease. This study is an effort to investigate the proposed association between these two disease entities and to identify the factors that increase the risk of this association. Methods: A cross sectional study from a teaching hospital in Bhopal city of central India. Total80 patients with metabolic syndrome were included in this study. Metabolic syndrome patients required to fulfil NCEP-ATP III criteria and 80 patients without metabolic syndrome were allocated into the control group. The biochemical parameters like: Fasting Glucose, Lipid Profile, Thyroid Profile, Hs-CRP, FINS, HOMA-IR levels were determined for assessment of metabolic dysfunctions. Results:Fasting blood sugar, Total cholesterol, LDL and TAG level of metabolic syndrome subjects are significantly increases compare than to control group. Abnormal thyroid functions were found in metabolic syndrome group compare to control group. Hs-CRP, FINS and HOMAIR level of metabolic syndrome subjects are significantly increases compare than to control group. Conclusion: Our study suggests that a slight increase in serum TSH might be a risk factor for metabolic syndrome. Therefore, the screening of thyroid level essential to reduce the severity of disease and further investigations are needed to evaluate the mechanism of this correlation.