European Journal of Molecular & Clinical Medicine

Abstract

The aimofthisresearch work wasto prepare and characterize different crystal forms of Febuxostat which is Xanthine oxidase inhibitor, used as an Antigout agent, Febuxostat recrystallized by Ultrasonication from mixture of various batches of acetone-water, ethanol-water, methanol-water and the resultant mixture were stored for 7 days at room temperature. The crystals obtained from above method were characterized by FT-IR, Differential Scanning Calorimetry, Scanning Electron Microscopy and X-ray Powder Diffractometry to investigate changes in physical properties of drug. X-ray Powder Diffractometry study reveals decrease in % Crystallinity which indicates amorphous nature. Scanning electron microscopy shows needle shaped morphology with methanol- water and acetone- water batches and irregular rod shaped morphology with ethanolwater batch, while Differential scanning colorimetry shows shift in Endothermic peak to quite lower temperature which indicatessharp decrease in melting point for batches E2, E5 and E10.FTIR reveals arrangement of functional group which shows characteristic changes in frequencies for different batches of mixture of acetone-water, ethanol-water, and methanol-water.