Clinico-radiological outcomes of platelet rich plasma versus steroid via epidural route in patients with lumbar degenerative disc disease: A prospective triple blinded randomized control study
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 2, Pages 1280-1289
Introduction: Low back pain is one of the leading causes of physical disability in both old and younger age group. It has enormous effects on socioeconomic status and health of people. Inter vertebral disc degeneration is an active process which involve changes in cellular microenvironment and tissue that eventually leads to structural breakdown and impairment of inter vertebral disc function. These changes cause back pain. Epidural steroid injection is a well-established modality in providing pain relief and is widely practiced. PRP (Platelet rich plasma) is a new upcoming modality with promising regenerative effects. In recent literature its use in treatment of back pain is being encouragingly promoted and is under evaluation.
To evaluate clinical outcomes of Platelet rich plasma in patients of degenerative disc disease with predominant radicular pain.
Subjective and objective comparison of effects of platelet rich plasma and dexamethasone with bupivacaine.
To evaluate evolution of MRI changes post P-PRP/Epidural steroid injections.
Methods: Patients of radiating low back pain were included after 6 weeks of failed conservative management. They were divided into two groups A and B of 15 each. Group A were given epidural P-PRP (pure-PRP) (8ml) injection in epidural space and group B were given dexamethasone 2ml + bupivacaine 0.5% 2ml + 4ml Normal saline. Groups were evaluated on basis of VAS lower back, VAS leg pain, MODI score and Pfirrmann grade in MRI
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