Hypertension in the Elderly: A Link Between High-density Lipoprotein Cholesterol and Renal Function
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 3211-3221
AbstractBackground:Few studies have looked into the possible link between renal function and high-density lipoprotein cholesterol (HDL-C) in elderly people with primary hypertension. As a result, the current study's goal was to assess the link between HDL-C and renal function in senior hypertension patients.
Methods:In our cross-sectional study, a total of 14,644 senior hypertension individuals were included. The patients were divided into two groups based on their serum HDL-C levels and their glomerular filtration rate (GFR) values. To compare the parameters among the groups, a one-way analysis of variance was employed. For multiple comparisons, the Bonferroni correction was used. Confounding influences were controlled using an analysis of covariance. The chi-square test for categorical data was used to examine the significance of differences between three or more groups.
Results:According to tertiles of HDL-C and tertiles of HDL-C/total cholesterol ratio (all P for trends <0.05), serum creatinine and uric acid were adversely associated to HDL-C level, but GFR was positively connected to HDL-C level in elderly hypertensive patients. The link between HDL-C and renal function was stronger in male elderly hypertension patients than in female elderly hypertensive patients. In hypertensive older people, low HDL-C was linked to renal insufficiency and proteinuria (P<0.05). When compared to the "normal renal-filtrator," the elderly "renal-hyperfiltrator" had a lower HDL-C level (P<0.05). By GFR stratum, there was an inverted "V" shape between HDL-C and GFR.
Conclusion:Low HDL-C levels are linked to poor kidney function in elderly hypertension patients, according to our findings. Glomerular hyperfiltration may also alter HDL-C levels, and sex may have a role in the relationship between HDL-C and renal function in senior hypertension patients.
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