European Journal of Molecular & Clinical Medicine

Abstract

Objective: The elderly has a significant morbidity and mortality rate from chronic kidney disease (CKD) and cardiovascular disease (CVD). In CKD patients, low levels of high-density lipoprotein cholesterol (HDL-C), a conventional CVD risk factor, are prevalent. In the community-dwelling population, nothing is known regarding the link between low HDL-C and renal impairment.
Methods: This was a population-based cross-sectional study with 4,753 people participated, which was a retrospective study. The Modification of Diet in Renal Disease (MDRD equation) equation was used to compute the estimated glomerular filtration rate (eGFR). Multiple logistic regression models and restricted cubic splines were used to investigate the links between renal impairment and low HDL-C.
Results: 620 (13.34 percent) of the 4,649 people who fit the criterion had low HDL-C levels of less than 40 mg/dl. Lower eGFR of 60 to 90 ml/min/1.73 m2 (OR, 2.03; 95 percent CI, 1.21–3.43) and marginal eGFR of 60 to 90 ml/min/1.73 m2 (OR, 1.26; 95 percent CI, 1.01–1.58) were significantly associated with low HDL-C in the fully adjusted model, compared to normal eGFR of 90 ml/min/1.73 m2. Furthermore, secondary studies employing the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation yielded consistent results. A substantial dose-response connection between eGFR and low HDL-C was found using fully adjusted cubic spline models (P for non-linearity, 0.356).
Conclusion: Renal dysfunction was independently and strongly linked with low HDL-C in this general senior population, and the incidence of low HDL-C increased with decreasing eGFR, suggesting that even minor changes in renal function may be associated with changed lipid levels.