Abstract

Background: In individuals with end-stage renal disease (ESRD), those on hemodialysis, and those with stage 3–5 chronic kidney disease, reduced kidney function is linked to low levels of high-density lipoprotein cholesterol (HDL-C) (CKD). However, there is a scarcity of epidemiological data on the link between HDL-C levels and renal function in the general population with roughly normal kidney function, and the results are conflicting. The goal of this study was to see if there was a link between HDL-C levels and estimated glomerular filtration rate (eGFR) in an Indian community.
Methods: This was a cross-sectional survey conducted in the community. During routine health status assessments, a total of 4925 participants (ages 18–96 years; mean, 51.30±11.98 years) were recruited. Each participant's age, smoking status, and history of hypertension and diabetes mellitus were all determined using a questionnaire. We took each participant's BMI, waist circumference, systolic and diastolic blood pressure, as well as fasting glucose, total cholesterol, triglyceride, HDL-C, low-density lipoprotein cholesterol, and uric acid, and serum creatinine levels. The Modification of Diet in Renal Disease equation was used to calculate eGFR.
Results: The first quartile (lowest quartile) of eGFR had a greater HDL-C level than the fourth quartile (the highest quartile). Additionally, as eGFR decreased, HDL-C levels declined. HDL-C levels were related to eGFR (r=0.16), according to Pearson's correlation analysis. HDL-C was shown to be linked with all quartiles of eGFR in the subjects after controlling for various covariates.
Conclusions: In a community-dwelling general population, HDL-C was found to be linked with kidney function independently. As eGFR fell, the link between low HDL-C levels and lower eGFR became stronger.