Paraquat (PQ) is a frequently used herbicide that is cheap and easy to obtain for individuals living in rural regions. A small amount of PQ intake could be fatal, although the best treatment is still being debated. Extracorporeal treatments (ECTR) have been used in the treatment of PQ poisoning, although there is insufficient evidence to demonstrate that they are superior to conservative therapy. The most prevalent treatments are haemodialysis (HD) and haemoperfusion (HP), while some institutions now use HP–HD concurrent therapy. The goal of this study is to see if haemopurification therapy can reduce mortality when compared to standard care. This one-year hospital-based study was conducted at a tertiary care center's P.G. department of Nephrology and renal transplant. A total of 20 patients were recruited for the study after evaluating exclusion and inclusion criteria.Despite the intervention with hemoperfusion, paraquat patients had the worst clinical outcome in this trial, with a survival rate of 5% (n = 20).