European Journal of Molecular & Clinical Medicine

Abstract

Background:Accumulating studies have suggested that all ages people are susceptible to
SARS-CoV-2 infection, which can result in severe and even fatal respiratory diseases.
The present study is to evaluate the determinants of disease severity and death among
young adults affected with COVID-19.
Materials and Methods: This prospective study includes a cohort of 100 adult patients
who presented to Victoria Hospital and Bowring and Lady Curzon Hospital attached to
BMCRI, Bangalore and were diagnosed with Covid-19 between May 2021 to August
2021. Patients were diagnosed with Covid-19 when symptomatic for Covid-like
symptoms and had a positive SARS-CoV-2 nasopharyngeal PCR.
Results: There was no significant association between sex and outcome. Proportions of
comorbidities was higher among the non-survivors, however no significant association.
This study showed that significantly higher pulse rate (95±16 vs 115±19), respiratory
rate (22±4vs26±3), TC (11699.1±4624.2vs15053.5±7988.6), Urea (38.6±35.4vs63.2±75.7)
and HRCT thorax (12±6vs18±5) was found among the non survivors, compared to
survivors, p<0.05.
Conclusion: Comparing with studies of all-age patients, a lot of clinical factors such as
sex, comorbidities and some clinical symptoms, showed no significant difference
between non-survivors and survivors in severely young adults, indicating that
characters of young adults were far more different from older patients in severe
COVID-19. We hence propose that vitals, Total counts, RFT values especially in CKD
patients and HRCT thorax severity score should be assessed upon admission for
patients, despite not previously documented among young adults.