Comparative Study of Rocuronium Bromide and Succinylcholine Chloride for Endotracheal Intubation During General Anesthesia
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 5016-5023
AbstractBackground: Rocuronium mimics the actions of succinylcholine which is the quick onset of neuromuscular blockade without the latter's side effects and can be used in place of it. The goal is to compare rocuronium bromide and succinylcholine chloride intubating settings and hemodynamic consequences.
Methods: N= 60 patients belonging to ASA I and ASA II of either sex posted for various elective surgeries requiring endotracheal intubation were selected for the study. They were randomly allotted into 2 groups containing N=30 each. Group I received Rocuronium Bromide 1.2 mg/kg i.v and Group II received Succinylcholine Chloride 1.5 mg/kg i.v to facilitate endotracheal intubation. Intubation was attempted at 60 seconds Hemodynamic responses were recorded before intubation, immediately after intubation, and every 2 min for 15 min and compared in two groups
Results: The intubating conditions in group I, N=28 patients out of n=30 had excellent intubating conditions with n=2 patients having good intubating conditions. In group II patients, N=27 patients had excellent intubating conditions with N=3 patients having good intubating conditions. We did not find any case with fair or poor intubating conditions in this study. The clinical duration of action of Group I range from 60 to 75 minutes with a mean duration of 66.79 minutes. The clinical duration of action of Group II ranges from 4 to 8 minutes with a mean duration of 5.83 minutes.
Conclusion: Rocuronium bromide 1.2 mg kg body weight produces good to excellent intubating conditions in all the patients at 60 seconds with a mean onset time of 76.09 ± 9.15 seconds. Rocuronium bromide is a safe alternative to succinylcholine chloride for rapid sequence induction in adult patients in situations where succinylcholine is contraindicated and in whom there is no anticipated difficult airway.
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