European Journal of Molecular & Clinical Medicine

Abstract

Aim: To see if there was a link between sputum eosinophil counts, serum
immunoglobulin E (IgE), and asthma severity.
Material and methods: It was a prospective observational study conducted in the
department of pulmonary medicine at TMMC & RC, Moradabad for one and half year
among 62 patients diagnosed as asthma on the basis of spirometry. All the study
participants were instructed to cough sputum into sterile plastic containers. Total IgE
levels more than 100 IU/mL was taken as abnormal. The degree of reversibility in
forced expiratory volume 1 s (FEV1) of 12% and 200 ml from the prebronchodilator
value was considered as diagnostic for asthma as per American Thoracic Society
standards and GINA 2019 guidelines.
Results: Mild, moderate and severe bronchial asthma was revealed in 35.4%, 29.2%
and 35.4% of the subjects respectively. S.E.C. and Sr.IgE level increase along with
severity of asthma with statistically significant difference. According to Pearson
correlation analysis, significant positive correlation was found between S.E.C and
Sr.IgE.
Conclusion: According to the data, both SEC &IgE are connected to asthma severity.
Asthma is associated with eosinophilic inflammation, which is a common symptom. As
SEC evaluation is a simple, inexpensive & noninvasive diagnostic approach of airway
inflammation, it could be the preferable approach for monitoring airway inflammation
and guiding therapy in day-to-day practice.