European Journal of Molecular & Clinical Medicine

Abstract

Background: The present study aimed to investigate the clinical significance of urinary Kim-1 level in type II diabetic patients with and without nephropathy and to evaluate its relation to various clinical and laboratory parameters as an early predictor of diabetic nephropathy.
Methodology: The prospective study was conducted at Department of Medicine at Dr M.D.M. Hospital, Jodhpur. Attached to Dr. S.N. Medical College to study the detection of Kidney injury molecule-1 (Kim-1): An early biomarker for nephropathy in type II diabetic patients attending the Medicine Outdoor and Indoor at M.D.M. Hospital, Jodhpur. It includes 75 patients whose serum creatinine level was less than 1.5mg/dL. Diabetes was defined as fasting plasma glucose ≥126 mg/dL according to WHO criteria.
Results: Kim-1 is found raised in 68% patients and with normal albuminuria and microalbuminuria also significantly correlated with other variables i.e. fasting blood sugar, HbA1c p value is less than 0.001 for all these variables. So kim-1 can be used to diagnosis early nephropathy as a sensitive, rapid, noninvasive test in diabetes. With these we conclude KIM-1 is a good for early detection of Diabetic nephropathy and it is nicely correlating with urinary microalbumin level which is gold standard for detection of early nephropathy.