European Journal of Molecular & Clinical Medicine

Abstract

Background:The discovery of early ovarian cancer indicators is critical for improving the patient diagnosis, therapy effectiveness, and prognosis of the ovarian tumors
Objective: To study the role of preoperative red cell distribution width (RDW), mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and CA125 in the differential diagnosis of epithelial ovarian tumors
Methods:We carried out a cross-sectional study in 90 patients diagnosed withthe ovarian pathology. They were assessed clinically and later admitted. Routine investigations along with cancer biomarkers like CA 125, RDW, MPV, and NLR were tested. Patients were posted for Laparotomy with hysterectomy/Ovarian cystectomy and specimen sent for histopathology. They were followed post operatively.
Results:60% of the cases were benign and 7.8% were malignant. All the benign cases were <45 years. Malignancy was slightly more in nulliparous women compared to multiparous women. Biomarkers like CA 125, MPV and NLR were significantly elevated in malignant cases compared to benign cases. All the cases having RMI <25 were benign. All the biomarkers were significantly increased in borderline and malignant cases compared to the benign cases.
Conclusion:There was significant association observed between CA125, MPV, NLR and ovarian tumours. CA125, NLR are positively correlated whereas MPV was negatively correlated. The combination of these biomarkers or at least 2 or 3 biomarkers are suggested for early stage diagnosis of pelvic mass with high sensitivity and specificity. The hematological parameters such as MPV, NLR along with CA125 are useful in the detection of the malignant ovarian tumours.