Disease profile with its updated diagnostic assay in Leprosy patients attending IGIMS, Patna: A tertiary care hospital of Bihar
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 5384-5395
AbstractIntroduction: Leprosy is considered a public health issue in countries where the annual
prevalence rate is greater than 1 case per 10,000 inhabitants. It is endemic in several
countries with low levels of social and economic development, especially India, with the
highest absolute number of cases in the former. In 2018, 208,619 new leprosy cases were
registered worldwide by the World Health Organization (WHO).
Aims & Objectives: to assess bacteriological index in these sample, to correlate these
findings with the newer techniques(ELIZA)m
Data and methods: A total of 106patients selected who were attending General
Medicine Department & V.D. Department at IGIMS, Patna and investigated at
Microbiology Department for slit skin smear examination. Blunt, narrow scalpel was
introduced into the nose and a piece of mucous membrane was taken for nasal smear
examination. The smears were examined under oil immersion lens to see red AFB
arranged singly or in groups / bundles (Globi).
Results: The most common form of leprosy observed in the present study was
borderline leprosy (BB) and Lepromatous leprosy (LL). Both the forms constituted
equal proportion of patients (24.5%). The sensitivity and specificity of ELISA was
48.42% and 72.73% respectively.
Conclusions: It was found that sensitivity; specificity, positive predictive value, and
negative predictive value of enzyme-linked immunosorbent assay (ELISA)
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