European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Postoperative pain management is essential for an early postoperative recovery. In spinal decompression surgery, nociceptive pain occurs due to surgical tissue injury to soft tissues and bony structures. And also manipulation of neurological tissue leads to neuropathic pain. Duloxetine (SSNRI) has an antinociceptive effect and it interfere with occurrence of chronic post surgical pain by modulating pain pathways. Duloxetine reduces acute postoperative pain as well as reduces dose of analgesic consumption.
Material and Method : 80 patients of ASA grade 1 and 2 were randomized into 2 groups as Group I (placebo, n=40), Group II (Duloxetine 60 mg, n=40). The patients received placebo or the study drug 1 hr before and 24 hr after surgery. Demographic data, vital signs, postoperative pain scores and any side effects were recorded.
Results: Time for first rescue analgesia was significantly longer in group II as compared to group I. Duloxetine 60 mg provided better analgesia (similar NRS score) as compared to placebo.
Conclusion: Our data suggest that Duloxetine 60 mg provides better post operative analgesia than placebo in patients undergoing Lumbar Spine Surgery.