A Prospective Study on Hospitalized Dermatology Patients and Analysis of Antibiotic Susceptibilities of Skin Wound Flora in Lucknow
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 1, Pages 1552-1556
AbstractBackground: Results of an ongoing surveillance of antibiotic resistance in hospitalized dermatology patients are presented. Bacterial isolates cultured from patients with skin wounds admitted to a tertiary care dermatology inpatient unit from May 2020 through Oct 2021 were evaluated for resistance to commonly used antibiotics. Our results show an alarming trend toward antibiotic resistance
Observation: In superficial skin wounds, Staphylococcus aureus constituted 77% of isolates. In leg ulcers, the frequencies of S aureus and Pseudomonas aeruginosa were approximately equal, constituting 43% and 42% of cultures, respectively. Fifty percent of S aureus isolates from leg ulcers were resistant to oxacillin, with 36% of pseudomonad isolates resistant to ciprofloxacin. In superficial wounds, oxacillin resistance in S aureus approached 25%. A comparison of antibiotic resistance profiles using data collected in 1992 for patients admitted to the same inpatient service revealed a marked increase in oxacillin and ciprofloxacin resistance in S aureus and P aeruginosa in leg ulcers, respectively (from 24% to 50% oxacillin resistance in S aureus and from 9% to 24% ciprofloxacin resistance in P aeruginosa), and superficial wounds (24% to 36% ciprofloxacin resistance in P aeruginosa).
Conclusions: This study demonstrates the rapid emergence of antibiotic-resistant bacteria as a problem of grow- ing significance in hospital dermatology and highlights the importance of local surveillance programs to aid in selecting antibiotic treatments
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