• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 9, Issue 3
  3. Author

Online ISSN: 2515-8260

Volume9, Issue3

Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions

    Lachhima Bhandari, Mohanvir Kaur, Vijay Kumar Bodal, Chettan Dass

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5676-5687

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Background:Oesophageal cancer is the eighth most common cancer and sixth in cancer
related mortality, worldwide. The current study was carried out to see the role of three
markers (P53, HER2, EGFR) in various oesophageal lesions, their association in cancer
progression and their role as tumour markers.
Materials and Methods: Study was conducted on 100 cases of oesophageal lesions
consisting of both neoplastic and non-neoplastic spectrum. Immunohistochemistry was
performed on all the specimens for three markers as per the set criteria and expression
of these markers was studied and scoring was done accordingly.
Results: Present study was conducted on 100 cases with oesophageal lesions both
neoplastic and non-neoplastic. Parameters like age, gender, family history, alcohol
intake, cigarette smoking and location of lesion in oesophagus were also studied.
Expression of P53, Her2, EGFR were studied using IHC.
Conclusion: P53, HER2 and EGFR show a strong association with EC and
premalignant lesions, the absence of their expression in normal oesophageal tissue and
non-neoplastic conditions, points out their role in development of EC and tumour
progression. Out of the three markers, P53 has the strongest association with EC. HER2
overexpression was more in case of EAC than ESCC, indicating its importance in
guiding further treatment. EGFR over- expression was noted in fewer cases.
Keywords:
    P53 HER2 EGFR oesophageal cancer IHC
  • PDF (744 K)
  • XML
(2022). Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions. European Journal of Molecular & Clinical Medicine, 9(3), 5676-5687.
Lachhima Bhandari, Mohanvir Kaur, Vijay Kumar Bodal, Chettan Dass. "Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions". European Journal of Molecular & Clinical Medicine, 9, 3, 2022, 5676-5687.
(2022). 'Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions', European Journal of Molecular & Clinical Medicine, 9(3), pp. 5676-5687.
Role of EGFR, HER2 and P53 in the Spectrum of Oesophageal Lesions. European Journal of Molecular & Clinical Medicine, 2022; 9(3): 5676-5687.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 58
  • PDF Download: 90
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus