European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Cisatracurium is one of the ten stereoisomers of Atracurium and is devoid of
histamine induced cardiovascular effects. The neuromuscular blocking potency of
Cisatracurium is approximately three-fold that of Atracurium. Neuromuscular transmission
was assessed by recording the muscle twitch response to train-of-four nerve stimulation.
Material and Method: This is a prospective study was conducted in the Department of
Anesthesiology, Tertiary care Teaching Hospital over a period of 1 year among 140 patients
aged between 20 and 45 years. Study was performed in 140 patients aged 20-45 years
weighted 40-70 kilograms with ASA physical grading 1 and 2 of either sex scheduled for
elective laparoscopic surgery. Monitoring – ECG, non-invasive blood pressure, pulse
oximetry, temperature and capnography (EtCO2). In operation theatre intravenous cannula of
proper size was inserted into the largest vein on the forearm and an infusion of lactated
ringer’s solution was started at a rate of 5 ml/kg/hr. Induction – inj. Propofol 2 mg per kg.
Patients were divided into 2 groups: Group 1 - 70 patients were given atracurium 0.5 mg per
kg for induction. Group 2 - 70 patients were given cisatracurium 0.1 mg per kg for induction.