European Journal of Molecular & Clinical Medicine

Abstract

Interferon Gamma Release Assays (IGRAs) were developed for the indirect or immunologic diagnosis of tuberculosis infection; however, they have also been used to assist in difficult to diagnose cases of tuberculosis disease in adults, and to a lesser extent, in children, especially in those under 5 years old. Interferon-gamma release assay (IGRA)-positive rates and false-positive rates among the five age groups examined. Both rates were significantly different among age groups (all p-values <0.001). p-values were obtained by chi-square tests for trend. Interferon-gamma release assay (IGRA)-positive rates among the four anatomic types of uveitis and between patients with and without retinal vasculitis. The IGRA-positive rates were significantly different among the four anatomic groups (p = 0.001). Patients with retinal vasculitis had higher positive IGRA rate (p < 0.001) than those without retinal vasculitis. p-values were obtained using chi-square tests.