European Journal of Molecular & Clinical Medicine

Abstract

Background: Detrusor overactivity (DO) characterized by urgency, frequency, with or without urge incontinence occurs as manifestation of various urological disorders like over active bladder (OAB), neurogenic bladder, infection or inflammation of the lower urinary tract, resulting in adverse impact on quality of life. The antispasmodics are selected, depending on various factors like age, co-morbid conditions, tolerability and acceptability. Antimuscarinic antispasmodic agents are commonly used. With no universal consensus on antispasmodic choice, and few systemic studies reported   in the Indian literature regarding pattern of antispasmodic use in bladder overactivity, comparison of their efficacy and tolerability. Methodology: A prospective observational cohort study was done in 120 subjects with symptoms of detrusor overactivity attending outpatient department of Urology in Patna medical college and Hospital, patna Study duration of two years.. The various study groups under DO included OAB, neurogenic bladder and OAB with urinary tract infection. The pattern and criteria for antispasmodic drug selection were noted. Their efficacy was assessed in terms of symptom improvement using OABSS, ICIQ-SF and VAS score along with assessment of tolerability and patient acceptability of antispasmodics.
Conclusion: Various antimuscarinic antispasmodics commonly used in DO are equal in efficacy, tolerability and patient acceptability. Flavoxate being the most preferred antispasmodic in subjects with associated lower UTI.