European Journal of Molecular & Clinical Medicine

Abstract

Background: Diabetic retinopathy (DR) is one of micro vascular complications of Diabetes
mellitus and leading cause of blindness. Mean Platelet volume is a marker of average size and
activity of platelets. Larger platelets are younger and exhibit more activity and related to these
complications.Objective:to study the association between mean platelet volume and Type 2
Diabetes, and its correlation with diabetic retinopathy.Methods: In this study, 100 patients with
Type 2 diabetes and without retinopathy, 50 patients with type 2 diabetes and with diabetic
retinopathy and 50 healthy age and gender matched controls were chosen and evaluated
clinically and laboratory data including MPV, platelet count,HbA1C,Fasting and post prandial
blood glucose, lipid profile,creatinine levels were obtained and studied. All study was done by
SPSS software. Results: Mean MPV among subjects with DM with Retinopathy was 11.7 ± 1.3,
among subjects with DM without Retinopathy was 10.7 ± 0.9 and among normal controls was
8.8 ± 0.5. There was significant difference in MPV b/w 3 groups. In the study there was
significant positive correlation between MPV and duration of DM, FBS, PPBS and HbA1c i.e.
with increase in Duration of DM, FBS, PPBS and HbA1c there was increase in MPV and vice
versa