European Journal of Molecular & Clinical Medicine

Abstract

Background: Rocuronium Bromide, an intermediate acting amino steroid NMDR, is five to seven times less potent than Vecuronium used in this study was to compare time of onset, conditions of tracheal intubation, duration of action and hemodynamic parametres, either of the drugs are used to produce muscular paralysis.
Materials & Methods: Study was carried out by taking 60 adult patients, undergoing different elective abdominal surgery under general anaesthesia, in age group of 15-60 years with ASA physical status I or II,30 patients received 0.6 mg/kg of Rocuronium bromide as Intubating dose and the other 30 patients received 0.1 mg/kg of Vecuronium bromide. Then neuromuscular blockade, endotracheal intubation of two non-depolarizing muscle relaxants were evaluated using a TOF in adductor pollicis muscles.
Results: In both the groups intubating conditions were either excellent or good. Intubating conditions with Rocuronium group were excellent in 86.67% and good in 13.33% patients while in Vecuronium group, intubating condition were excellent in 80% and good in 20% patients, which were comparable and statistically not significant (p=0.488). The onset of action of Rocuronium was found to be rapid compared to Vecuronium group with high statistical significance. (p=0.000).