European Journal of Molecular & Clinical Medicine

Abstract

Background:Globally, hypertensive disorders of pregnancy (HDP) are one of the major
causes of perinatal and maternal morbidity and mortality. These disorders are
characterized by increase in blood pressure (BP) which may be present before or
appear for the first time during pregnancy after 20 weeks with or without proteinuria
or evidence of multiorgan involvement and have been classified into preeclampsia (PE)
and eclampsia syndrome, chronic hypertension (CH), PE superimposed on CH, and
gestational hypertension. The HDP may complicate 5%–10% of all the pregnancies
with the prevalence of 6.9%–7.9% in India. Studies have shown that HDP accounts for
around 16% of 2.6 million stillbirths and 15% of perinatal deaths globally. Higher rates
of adverse perinatal outcome such as preterm delivery, low birth weight, birth asphyxia,
stillbirth, and early death have been reported worldwide in women having
HDP.Prematurity and preterm birth are documented as the most common cause of
perinatal death in Indian women with HDP. The present study was conducted with the
aim to know the type of hypertension affecting the pregnant women and perinatal
outcome.Aims and objectives:To determine the outcome of neonates born to mothers
with Hypertensive Disorders of pregnancy in comparison with neonatal outcome in
babies born to normotensive mothers.
Materials and Methods: A comparative case control study will be performed on
Neonates fitting into inclusion criteria from JAN 2019 to Jun 2020 and a
prestructuralperforma will be used to obtain detailed History taking, Clinical
examination .The comparison will be done between two groups. The study group, which
will include neonates born to mothers with either gestational hypertension,
preeclampsia or eclampsia. The control group, which will include all babies born to
normotensive mothers, matched forgestation with the study group during the study
period.
Results: The results showed that the primary and the secondary outcomes in the study
group was significantly poorer compared to control group. There was significantly high
rate of death among the neonates born in the study group (p< 0.05).Also there was
higher rate of meconium stained amniotic fluid (16%), more requirement of surfactant
(14%) and more requirement of NICU admission (31%) among the study group. There
was also higher rate of IUGR (20%) as well as higher rates of Low birth weights among
study group.