Oxidative Coupling Reaction for Spectrophotometric Determination of Phenylephrine Hydrochloride
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 10602-10606
AbstractPEH (phenylephrine hydrochloride) is a medication that reduces nasal congestion by restricting the blood vessels in the nasal mucosa. This medicine is also used to dilate the pupil and treat cold and rhinitis symptoms. EH is a sympathomimetic drug (-Adrienne) with the chemical name (R)-1-(3-hydroxyphenyl)-2-methylamino ethanol hydrochloride. This medication may help treat low blood pressure and relieve the symptoms of external or internal haemorrhoids.This study focused on the oxidative coupling reaction of phenylephrine with N, N dimethyl-p-phenylenediamine dihydrochloride and ferric chloride in a primary medium to produce a green-blue soluble dye product is the basis for this approach.0.1 gramme of phenylephrine in 100 mL of H2O was used to make a 1,000 g/mL PEH solution. 25 and 10 ml of the obtained solution were diluted to 100 ml with distilled water, respectively, to get 250 and 100 g/mL. Tulshiram syrup was used as a sample, and 50 mL was taken. After that, the oxidizing agent was made by dissolving 0.23 gramme FeCl3 in 100 mL distilled water. Dissolving 0.4 gramme of sodium hydroxide in 100 mL of distilled water yielded a sodium hydroxide solution.
The t-test method was utilized to evaluate the validity of the proposed method for precision with the standard method. Potentiometric titration of pure medication solution in anhydrous acetic acid with per-chloric acid was used for the evaluation. As a result, NNDPH and other existing approaches are compared. F = 3.22, t = 1.24; the obtained result was smaller than the tabular value for F, t. (required). The tabular value for F, t was F = 6.36, t = 2.776 at a confidence level of 95%, and for four degrees of freedom was F = 6.36, t = 2.776. As a result, these figures show that the proposed strategy is effective.PEH is a nasal decongestant that can help you breathe easier if you have a stuffy nose. It helps you breathe more easily by shrinking the blood vessels in your nose and sinuses.
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