European Journal of Molecular & Clinical Medicine

Abstract

Vaginitis is a term used to describe conditions that cause vaginal inflammation. It is one of the most common gynaecological disorders. The two most prevalent causes of vaginitis are candidiasis and bacterial vaginosis. Vaginal candidiasis (VC) is one of the most common reasons women see a gynaecologist.Candida is a form of yeast that is harmful in humans. Candida albicans and other Candida species such as Candida glabrata and Candida parasitosis are responsible for 90 per cent of vaginal fungal infection cases.This study aimed to develop muco-adhesive vaginal units, such as curcumin tablets and films, to treat vaginal candidiasis. Curcumin was sent as a free sample by Sava Health Care Pvt Ltd in Pune, India. Coloron Asia, Goa, India, and Research-Labs FineChem Industries, Mumbai, India, provided the hydroxypropyl methylcellulose (HPMC K15M) and xanthan gum (Pure, Food Grade), respectively. Acetone (Universal Labs, Mumbai, India), PEG 400.The water was distilled on hydroxypropyl methyl/Vis Spectrophotometer, FTIR Spectrophotometer, XRD (Advance D8), Texture analyzer (Brookfield, India), pH meter (Digisun Electronics, Mumbai, India), Magnetic stirrer (Remi equipment’s, Mumbai, India), Dissolution apparatus (Lab India Analytical Instruments Pvt. Ltd. Bangalore, India), Hot air oven.The water was distilled on-site.UV/Vis Spectrophotometer, FTIR Spectrophotometer, XRD (Advance D8), Texture analyzer (Brookfield, India), pH meter (Digisun Electronics, Mumbai, India), Magnetic stirrer (Remi equipment’s, Mumbai, India), Dissolution apparatus (Lab India Analytical Instruments Pvt. Ltd. Bangalore, India), Hot air oven.The morphological character of the drug was determined using XRD under various situations, including as a single drug, in a film, and in a tablet. In simulated vaginal fluid, a calibration curve was created—assessment of the Film. Tablet is evaluated.Drug and excipient flow characteristics are assessed. Based on the findings, it can be concluded that Curcumin mucoadhesive film and tablet formulations are feasible. It was determined that there was no interaction between the medication and the excipients.