European Journal of Molecular & Clinical Medicine

Abstract

Background: Staphylococcus aureus infections are one of the major infections in hospitals and the drug-resistant strain of S. aureus caused mortality and morbidity throughout the globe. In this study, we evaluated the S. aureus infection and their drug sensitivity patterns at Medicine department for 5 years.
Methods: The patients admitted at medicine word were participated in this study. All clinical samples were taken for bacteriological study. After identification of bacteria, the drug sensitivity patterns were carried out by disc diffusion methods.
Results: A total of 944 S. aureus isolates were analyzed. High sensitivity of S. aureus was observed for quinupristin/dalfopristin (100%), tigecycline (98.2), imipenem (98%), nitrofurantoin (97.6%), linezolid (97.3%), teicoplanin (97.1%) and vancomycin (95.1%). High resistance was recorded against penicillin G (91.9%), trimethoprim/sulfamethoxazole (56.9%) and tetracycline (33.2%). MRSA prevalence among the patients at IMS and SUM Hospital, Bhubaneswar was 27.8%. Highest proportion (80%) of MRSA was in burns unit.
Conclusions: Both MRSA and MSSA were highly susceptible to quinupristin/dalfopristin, tigecycline, linezolid, nitrofurantoin, ampicillin/sulbactam and vancomycin and showed high resistance to commonly used antibiotics such as gentamycin, erythromycin, levofloxacin and tetracycline. A majority of isolates were from pus specimen (68%).