Study to evaluate the effect of vitamin C supplement on pulmonary function test in COPDpatients.
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 10715-10721
Abstract
Introduction: A substantial body of evidence indicates that nutrition influences respiratoryhealth. Much of the nutrition research has focused on the intake of fruits, vegetables, and
antioxidant micronutrients, because lungs are subject to a wide range of oxidant induced insults
and because antioxidant defenses play an important role in protecting the lungs from damage.
Materials and methods: Seventy five patients with COPD were included in the study. In their
baseline clinical examination, malondialdehyde (MDA); red blood cell superoxide dismutase
(SOD) and erythrocyte glutathione peroxides (GPx) levels were measured. All the above
parameters were repeated after 12 weeks of supplementation with 1000 mg vitamin C daily.
Result: Serum MDA levels were significantly lowered, erythrocyte SOD and Gap activity were
significantly higher after supplementation of vitamin C. No significant improvement in FEV1
and FEV1/FVC was observed after 12 weeks of vitamin C supplementation.
Conclusion: The present study shows that the plasma lipid peroxide (MDA) levels were
decreased and antioxidants levels (GPx and SOD) increased after 12 weeks supplementation of
vitamin C in patients with COPD. Exogenous supplementation with vitamin C does not have any
significant effect on the spirometric measurements though it brings down the levels of MDA
showing attenuation of further damage.
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