European Journal of Molecular & Clinical Medicine

Abstract

Aim: To analyze the clinicopathological and immunohistochemical features of primary central
nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility
of the crush smear preparation in intraoperative diagnosis.
Material & Methods: 40 cases of PCNSL diagnosed in the Department of Histopathology, were
included in this study. Haematoxylin and Eosin (H and E) stained slides and
immunohistochemistry slides (which included a minimum of Leucocyte common antigen (LCA),
CD20 and CD79aof all these cases were retrieved.
Results: The mean age of the patients was 51.4 years and the median was 50 years (range 30-72
years). The male: female ratio in our study is 1:1. Of the 40 cases, one was a known case of
sarcoidosis (in remission). The only T-cell lymphoma case in our series had a prior history of
treatment for ulcerative colitis (in remission).
Conclusion: Our study shows that PCNSL is seen predominantly in immunocompetent patients
in India. The age of presentation is relatively young. Our study also stresses the utility of crush
smear preparation in establishing an intraoperative diagnosis.