European Journal of Molecular & Clinical Medicine

Abstract

Type 2 diabetes is linked to alcohol consumption. The link between alcohol consumption
and β-cell function, on the other hand, is still unknown. The purpose of this study is to
look at the link between them. 675 Indian men between the ages of 20 and 75 were
enlisted. The participants were first categorised into four categories: never drinkers,
abstainers, light drinkers (0.1-19.9 g/day), moderate drinkers (20.0-39.9 g/day), and
heavy drinkers (≥40.0 g/day), and then into two subgroups based on their body mass
index (BMI) (BMI< 25kg/m2 and BMI ≥25kg/m2). Confounders such as age, smoking
status, BMI, waist circumference (WC), blood pressure, lipids, and blood uric acid were
used to adapt the analysis process.Alcohol intake was linked to lower homeostasis model
assessment of β-cell function (HOMA-β) scores when compared to never drinkers,
regardless of BMI. In the BMI<25kg/m2 group, the homeostasis model assessment of
insulin resistance (HOMA-IR) was strongly connected with alcohol consumption
history, and in the BMI≥25kg/m2 group, it was significantly correlated with alcohol
consumption. The findings imply that alcohol intake is linked to β-cell dysfunction in
Indian community-dwelling men, regardless of BMI