European Journal of Molecular & Clinical Medicine

Abstract

Background: Abnormal uterine bleeding (AUB) is a major clinical problem in women of peri and post-menopausal age group. It accounts for 30%of outpatient population coming to a gynaecologist. Evaluation of AUB is important for ruling out endometrial carcinoma and its precursors. Endomed biopsy is an ideal method for obtaining endometrial sample with ease, low cost and without anaesthesia. To determine sensitivity, specificity, positive predictive value and negative predictive value of Endomed sampler, by comparing the histopathology reports of endometrial samplings with that of hysterectomy specimen, taken as gold standard. Methods: This study is carried out in 76 patients with abnormal uterine bleeding posted for hysterectomy. Endometrial sampling was done with Endomed in all patients. The histopathology report of endomed sample is compared with that of hysterectomy sample. Results: The mean age of study population in our study was 45.75 ± 7.19 years. The most common complaint was menorrhagia (39.5%), followed by polymenorrhagia (17.1%), dysmenorrhea and lower abdominal pain (14.5% each). Endomed sample was found to be adequate for 94.7% of the study population. Among the adequate samples, proliferative endometrium contributed to a 28.9%, followed by secretory endometrium (22.4%) and the least was hyperplasia with atypia (3.9%). Among the study population, 8 (10.5%) of them were found to have carcinoma endometrium with histopathology (HPR) report of hysterectomy specimen whereas 6 (7.9%) using Endomed sampling. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy was found to be 100%, 88.2%, 96.97%, 100% and 97.22% respectively for Carcinoma Endometrium. Conclusion: Endometrial sampling by endomed method is safe, easy to perform, highly sensitive and specific for diagnosis of endometrial carcinoma and its precursors. Endomed sampling can be used as an alternative to D&C for sampling of endometrium.