Intrathecal 0.5% hyperbaric bupivacaine with varying doses (30 μg Vs 60 μg Vs 90 μg) of buprenorphine in lower abdominal and lower limb surgeries; hemodynamic changes
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 2, Pages 2141-2146
AbstractBupivacaine hydrochloride is 2-piperidenecarboxamide-1-butyl-N-(2, 6 dimethyl phenyl) monochloride, a monohydrate is a white crystalline powder that is freely soluble in 95% ethanol, soluble in water, and slightly soluble in chloroform or acetone. Local anesthetics mainly work on the cell membrane of the axon. The considerable transient rise in sodium ion permeability that's also required for impulse transmission is inhibited. Depolarization in response to the stimulus is thereby blocked, and the resting membrane potential is preserved. A pre-anesthetic check-up was done one day before the surgery. Patients were evaluated for any systemic diseases and laboratory investigations were recorded. The procedure of SAB was explained to the patients and written consent was obtained. The preparation of patients included a period of overnight fasting. Hemodynamics during the operative period was similar in the 30 mcg group and 60 mcg, but for the 90 mcg group incidence of hypotension and respiratory depression was observed for a few cases.
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