European Journal of Molecular & Clinical Medicine

Abstract

Objective: Perforation is the second most common complication of peptic ulcer disease(PUD). Various treatment modalities has been given in literature but still omentum Graham’s patch repair is treatment of choice. The clinical course of disease after perforation is rarely studied. With this aim in the mind, present study is being conducted to find out complications in post-operative patient of peptic perforation peritonitis. 
Material and Method: This is a prospective observational study in which all operated patients of Peptic Perforation Peritonitis received Anti Helicobacter therapy for two weeks and additional two weeks of PPI afterwards. All patients were followed up for endoscopy at different interval upto 2 years. All patients were tested for rapid urease test(RUT).
Results: In this study total 56 operated patients of peptic perforation peritonitis had complete follow-up upto 2 years. At 2months: 7.14%patients had symptoms of PUD. Upper gastro-intestinal endoscopy was significant in 5.36% and RUT was positive in 3.57%patients. At 6months: 23.21%patients had symptoms of PUD and 21.42%patients had endoscopy findings. RUT was positive in 17.86%patients. At 1year : 16.07%patients had symptoms of PUD and all patients had significant endoscopy findings. RUT was positive in all patients.At 2year :12.5% patients had PUD and all patients had  significant endoscopic findings. RUT was positive in all cases.
Conclusion: This study concludes that all operated patients must undergo follow up endoscopy with rapid urease test. Even though H.Pylori kit administered to all patients, re-infection is observed. Frequency of endoscopy can be reduced depending on patient’s symptoms and endoscopic findings.