European Journal of Molecular & Clinical Medicine

Abstract

Background: Currently Gastroesophageal reflux disease (GERD) is the most common esophageal disorder, accounting for nearly 75% of all patients with esophageal disorders and around 25-30% of the general population in the west. Most studies from India suggest that these might be less in the Indian population. Most but not all patients with GERD are relieved by treatment with proton pump inhibitors and other anti-reflux treatment. Upper Gastrointestinal endoscopy also known as esophagogastroduodenoscopy (EGD) is the best test for the evaluation of the proximal gastrointestinal tract.
Objectives: To study the clinical and endoscopic profile of patients with GERD; and its response to proton pump inhibitors and prokinetics.
Methods: The study was a prospective study that included 100 in patients and out patients seen in the Department of Medicine at, All India institute of medical sciences, Patna. Study duration of two years. with reflux symptoms, with a score of more than 8 in the FSSG questionnaire, and who met the inclusion criteria with no reasons for exclusion, and consented for the study. Patients were analyzed clinically and by endoscopic profiles and their response to PPI and Prokinetic combination assessed at the end of 4 weeks of therapy.
Conclusion: Gastroesophageal Reflux Disease is a common problem with heartburn and regurgitation being the most common presenting symptoms affecting males more than females. Non erosive reflux disease is commoner than reflux esophagitis on endoscopic assessment. A combination of proton pump inhibitors and prokinetics.