European Journal of Molecular & Clinical Medicine

Abstract

Background: Dyspepsia is a chronic or recurrent pain or discomfort centered in the upper abdomen; patients with predominant or frequent (more than once a week) heartburn or acid regurgitation, should be considered to have gastro esophageal reflux disease (GERD) until proven otherwise.⁽¹⁾Helicobacter pylori, a curved rod shaped bacterium, has been consistently associated with patients having acid peptic diseases, which plays a major role in its etiopathogenesis.²
Objectives: To estimate the prevalence of Helicobacter pylori infection in patients with dyspepsia undergoing upper gastrointestinal endoscopy.
Methods: Hundred cases of dyspepsia, studied clinically as per the proforma from August 2019 to June 2022, were subjected to upper gastro-intestinal endoscopy under topical anaesthesia, during which biopsies, from the pathological areas were taken. Biopsy specimens, were immediately inoculated into freshly prepared urea broth containing phenol red as the indicator. Positive test for Helicobacter pylori was indicated by change in colour of the medium from yellow to pink or red. The other biopsy specimens were sent for routine histopathology and special staining with Giemsa stain.
Conclusion: H.Pylori is consistently associated with patients of acid peptic disease and has a high prevalence in cases of ulcer dyspepsia than non-ulcer dyspepsia.