European Journal of Molecular & Clinical Medicine

Abstract

Context:Organophosphorus (OP) poisoning is a common mode of suicidal poisoning. These compounds are widely available in developing country like India, resulting in high morbidity and mortality. The use of serum amylase in determining the severity of OP poisoning has showed promise.
Aims:This study was undertaken to estimate serum amylase levels in acute OP poisoning and to correlate it with the outcome.
Settings and Design:
Setting – tertiary care treating hospital
Design -cross-sectional observational study
Methods and Material:A hospital-based cross-sectional study was conducted on 80 patients who were clinically diagnosed with acute OP poisoning. Serum amylase was measured on days 1 and 2 of admission and correlated with clinical features and the end result.
Statistical analysis used was SPSS 23.0 version software, and the data was analyzed. To compare the variables across the groups, the H test and Chi-square test were used.
Results:The majority of the cases in the study (41%) were between the ages of 21 and 30. Males made up 65 % of the group, while females 28 %. Serum amylase levels were significantly elevated in patients with clinical features of OP poisoning. The median serum amylase level was 80 IU/l (IQR 50–224.5). Serum amylase levels were normal in 62.5 % (n-50), but elevated in 37.5 % (n-30). A bad outcome was linked to a persistently elevated serum amylase level on day 2.
Conclusions: Serum amylase levels is also considered as a prognostic marker of OP poisoning since it enables the first recognition of severity and to spot those in danger of developing the complications of OP poisoning.