COMPARATIVE STUDY OF FASTING INSULIN AND HOMA-IR IN RURAL AND URBAN T2D PATIENTS
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 285-290
AbstractIntroduction: Insulin resistance is a feature of a number of clinical disorders, including T2D/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so-called metabolic syndrome. Insulin resistance in skeletal muscle manifests itself primarily as a reduction in insulin-stimulated glycogen synthesis due to reduced glucose transport.
Material and Method: A cross-sectional study was conducted on 100 subjects of type 2 diabetes having an age group of 40-70 years from urban and rural area of Meerut, U.P., India for determination of HOMA-estimated insulin resistance (HOMA-IR).
Result: We found urban subjects had significantly higher fasting Glucose, fasting insulin and HOMA-IR values than rural subjects (p < 0.001).
Conclusion: Environmental and lifestyle changes resulting from industrialization and migration to urban environment from rural settings may be responsible to a large extent, for this epidemic of insulin resistance in Indians.
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