European Journal of Molecular & Clinical Medicine

Abstract

The first person to describe cavernous hemangioma was Hubert Luschka.1 In the year 1854, he
published the case of cavernous vascular brain tumor (“kavernöseBlutgeschwulst des Gehirns” –
German) and provided a detailed description of its gross macroscopic aspect. The first
histopathological description was given by the renowned pathologist Rudolf Virchow in the year
1863.2In histologic terms, cavernous angiomas (CA) are blood-filled cavities covered by a single
layerof endothelium. The intervening tissue includes microglia but no neural elements.3
At present, the terms cavernoma, cavernous hemangioma/angiomaand/or cavernous
malformation are being used interchangeably. We must also note that the terminologies
cavernoma, cavernous angioma, and cavernous hemangioma are misnomers since they tend to
point towards a neoplasticorigin.However, these represent true vascular malformations.