A STUDY ON RELATION OF DYSLIPIDEMIA IN PSORIASIS PATIENTS IN TERTIARY CARE HOSPITAL
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 11604-11610
Abstract
Background:To assess the statistically significant difference in the serum lipid profile levels in the psoriasis cases and healthy controls and to evaluate atherogenicity in psoriatic patients which is a risk factor for cardiovascular disease.Psoriasis is a common and recurrent proliferative inflammatory skin disease that has been influenced by abnormal plasma lipid metabolism, genetic, environmental, viral, immunological factors and with high frequency of cardiovascular morbidity and mortality. Biochemically Psoriasis leads to increased synthesis and degradation of nucleoproteins, it is also associated with changes in blood biochemistry. This study was done to establish the correlation of lipid profile in the psoriasis patients and also to evaluate the risk of atherogenicity in psoriatic patients which is a risk factor for cardiovascular disease. Blood samples were analysed for the following parameters in lipid profile, total cholesterol, LDL, HDL, Triglycerides. A significant relation was found with dyslipidemia and increased risk of atherogenicity in psoriasis disease and severity of diseases in which the risk factors and secondary causes of hyperlipidemia were excluded.Materials and Methods: Present study was done at Department of Biochemistry, Maheswara Medical College, Hyderabad and analysed fasting lipid profile in 160 patients diagnosed with mild to severe psoriasis and 160 age and gender matched healthy subjects as the control group in the period of 20 months.
Results: Subjects presented considerable risky elevation in lipid profile, serum total cholesterol (p<0.001), triglyceride (p 0.002), LDL-cholesterol (p<0.001), VLDL-cholesterol (p<0.001) and free fatty acids (<0.001) were found to be significantly higher than in control group. Significant decrease in statistical analysis was observed in HDL (p<0.001) levels of the two groups. Significant positive correlation in total cholesterol, LDL, VLDL and FFA was found between mild, moderate and severe psoriasis (PASI score) as compared with controls.
Conclusion: Present data suggest that psoriasis patients must be considered as a group at high risk for cardiovascular, since psoriasis per se seems to be associated with risk changes in the lipid profile. We conclude that psoriatic patients should be evaluated and followed up for the risk of hyperlipidemia and cardiovascular diseases.
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