ALTERATIONS IN LIPIDS LEVEL IN SUBCLINICAL HYPOTHYROIDISM
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 11626-11632
AbstractBackground: Although overt hypothyroidism is linked to lipid metabolic abnormalities, there are mixed results when it comes to the degree of lipid alterations in subclinical hypothyroidism (SCH).
Patients and Methods: In a cross-sectional investigation, the serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were assessed.
Results: Patients with SCH had significantly higher mean serum total cholesterol (TC), triglycerides (TG), and very low-density cholesterol (VLDL) than controls (P<0.05). Patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L had higher mean TC, TG, and low-density cholesterol (LDL) concentrations than those with serum TSH equal to or less than 10 mU/L, although the difference was not statistically significant. The concentration of blood high-density cholesterol (HDL-C) and the amount of serum TSH had no correlation.
Conclusions: High TC, TG and VLDL were observed in our patients with SCH.
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