Study and Comparison of Renal Function tests in Pre-eclampsia and Eclampsia with Normal Healthy Pregnant Women
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 11693-11699
Abstract
Background:Preeclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. It rarely presents before 20 weeks of gestation like in hydatidformmole.Eclampsia is a syndrome with one or more episodes of convulsions in association with preeclampsia .In India, the national incidence of hypertensive disorders is 15.2%,with incidence in nulliparous women being four times greater than in multipara.With severe renal involvement, glomerular filtration may be impaired and the plasma creatinine concentration may begin to rise.Elevated uric acid is another component of the preeclampsia. Although hyperuricemia does correlate with maternal morbidity, there is an even stronger association of uric acid with the risk for small birth weight infants and with overall foetal mortality. The hyperuricemia of preeclampsia has been variably suggested to be associated with lactic acidosis, altered renal functions or oxidative stress.AIM: To Study and compare renal function tests in Pre-eclampsia and Eclampsia with normal healthy pregnant women and assess the ante-partum severity in both the diseases.Materials and Methods: Study was conducted on 70 pregnant women admitted with pre-eclampsia and eclampsia and 35 normal pregnancy patients in between 19-26 yrs of age in third trimester of pregnancy.
Results: There is a increase in Diastolic blood pressure in mild pre-eclampsia and significant increase in severe pre-eclampsia and eclampsiapatientswhen compared to controlsThere is a increase in serum uric acid in mild pre-eclampsia and significant increase in all parameters insevere pre-eclampsia and eclampsia patientswhen compared to control.
Conclusion: There is a derangement of parameters of RFT in severe preeclampsia and eclampsia.But there was no significant elevation in mild pre-eclampsia.Persistant Renal parameter that increased was Uric acid. These can be taken as a predictor of the disease.
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