European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Leptin is an ob gene encoded adipocyte derived hormone which serves as a
relay link between metabolic signals and brain to regulate the hypothalamic pituitary ovarian
axis. Leptin is associated with obesity which is a major cause of PCOS in women of
reproductive age group.
Aim: The purpose of study was to evaluate the association of serum leptin concentration with
gonadotrophins and prolactin in women with PCOS.
Material and Method: Itwas a case control study conducted for a span of oneyear at one
year, at Department of Biochemistry in collaboration with department of Obstetrics and
Gynaecology, MKCG Medical College and Hospital from December 2018 to December
2019, where 60 PCOS subjects and 30age matched normal ovulatory controls of 15 – 30
years age group with BMI<25 kg/m2 were included. BMI was calculated and study
population was divided into 2 groups that is Lean PCOS group with BMI < 25kg/m2 and
Obese PCOS group with BMI ≥ 25kg/m2.Serum leptin, gonadotrophins and prolactin were
estimated on 2nd or 3rd day of menstrual cycle. Data was represented as mean and standard
deviation and statistical analysis was done in SPSS version 25. Data analysis was done using
one-way ANOVA test, correlation was calculated by using the Pearson’s correlation method.
A ‘p’ value of <0.05 was taken as significant.