European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Leptin is an ob gene encoded adipocyte derived hormone which serves as a relay link between metabolic signals and brain to regulate the hypothalamic pituitary ovarian axis. Leptin is associated with obesity which is a major cause of PCOS in women of reproductive age group. Aim: The purpose of study was to evaluate the association of serum leptin concentration with gonadotrophins and prolactin in women with PCOS. Material and Method: Itwas a case control study conducted for a span of oneyear at one year, at Department of Biochemistry in collaboration with department of Obstetrics and Gynaecology, MKCG Medical College and Hospital from December 2018 to December 2019, where 60 PCOS subjects and 30age matched normal ovulatory controls of 15 – 30 years age group with BMI<25 kg/m2 were included. BMI was calculated and study population was divided into 2 groups that is Lean PCOS group with BMI < 25kg/m2 and Obese PCOS group with BMI ≥ 25kg/m2.Serum leptin, gonadotrophins and prolactin were estimated on 2nd or 3rd day of menstrual cycle. Data was represented as mean and standard deviation and statistical analysis was done in SPSS version 25. Data analysis was done using one-way ANOVA test, correlation was calculated by using the Pearson’s correlation method. A ‘p’ value of