European Journal of Molecular & Clinical Medicine

Abstract

Background: Functional endoscopic sinus surgery (FESS) has been recommended as a
treatment option for chronic sinusitis patients who have failed to respond to medical
treatment. In order to maximize the visibility of the operative site during functional
endoscopic sinus surgery (FESS), it is critical to reduce bleeding. The goal of this study was
to examine the effectiveness of dexmedetomidine and magnesium sulphate as hypotensive
agents in FESS in adult patients in order to achieve a bloodless surgical field.
Materials and methods: Sixty patients aged between 18-65 years were randomly assigned into
two groups, the D group for dexmedetomidine (n = 30) the and M group for magnesium
sulfate (n = 30). Patients in the D group received a loading dose of 1 g/kg dexmedetomidine
in 100 mL saline solution 10 minutes before induction and a 0.5–1 g/kg/h infusion via syringe
pump throughout the surgery. Patients in the M group received 40 mg/kg magnesium sulfate
in 100 ml saline solution over 10 min as the intravenous loading dose 10 min before
induction,followed by a 10–15 mg/kg/h infusion.