European Journal of Molecular & Clinical Medicine

Abstract

Background- Chronic liver disease (CLD) causes pathological alterations in the
myocardium in addition to the typical hemodynamic abnormalities. Since the reduced
systemic vascular resistance usually compensates for overt heart failure, cardiac
pathology is frequently disregarded.
Methods- The current investigation was carried out at the Darbhanga Medical College
& Hospital, Darbhanga as an observational study. A total of 75 patients with chronic
liver disease were included in the study. After being interviewed, their demographic
data, symptoms, and presentation were collected. Then, all of the patients underwent
thorough physical examinations, 2D ECHO and ECG cardiological assessments, and
blood investigations.
Results: Patients without cardiac dysfunction had a mean age of 40.3 years, whereas
those with cardiac dysfunction had a mean age of 46.25 years. Cardiac dysfunctions in
CLD patients most frequently affected individuals between the ages of 51 and 60, and
96% of cases included men and 4% involved women. In 28% of individuals, QTc
prolongation was identified. Diastolic dysfunctions were common in 24% of CLD
patients, while systolic dysfunctions were common in 20% of them.
Conclusion- In order to consider the presence of CV dysfunction and cirrhotic
cardiomyopathy in CLD patients and estimate the risk of unfavourable cardiac events,
a high level of awareness is required. To enhance these individuals' prognoses, more
research is required on particular therapy approaches