European Journal of Molecular & Clinical Medicine

Abstract

Background: Diabetes mellitus type 2 (DMT2) is one of the most prevalent endocrine
illnesses, affecting about 135 million individuals globally. The disease's genesis is
unknown, but subclinical hemochromatosis has recently been identified as one of the
possible causes of DM. The purpose of this study was to look at the association between
serum ferritin as a measure of iron excess and diabetes and HbA1c.
Methods: This 12-month study was carried out in the Medicine department of Katihar
Medical College Hospital in Bihar, India. 46 patients with T2DM were used as cases in
this case control study. The control group consisted of 46 healthy individuals who were
age, gender, BMI, and haemoglobin percent matched to the case group. Blood samples
were tested for ferritin, haemoglobin, HbA1c, and fasting plasma sugar. Anaemia and
any other ailment or medicine that could alter ferritin levels were exclusion criteria.
Result: The Pearson correlation coefficient test, Student's t-test, Chi-square test, and
Odds ratio were used to assess the results statistically. Diabetics had considerably
higher mean serum ferritin levels than the control group (197.97± 75.99 gm/L vs. 64.24±
27.83 gm/L, p<0.001). In diabetic patients, there was a substantial positive connection
between HbA1c and serum ferritin (p<0.001). In this investigation, an OR of 11.64 was
also discovered.
Conclusion: Serum ferritin levels are associated with T2DM patients. This could be a
significant and independent predictor of the development of diabetes mellitus