ASSESSMENT OF MATERNAL THYROID HYPOFUNCTION AND PREGNANCY OUTCOME
European Journal of Molecular & Clinical Medicine,
2017, Volume 4, Issue 1, Pages 298-303
Abstract
Background: Obstetric factors may be responsible for some of the differences in neurologic outcomes seen in the offspring of women with maternal thyroid hypofunction compared with their euthyroid counterparts.Materials & Methods: 80pregnant women with hypothyroidism were subjected to assessment of thyroid profile that includes T3, T4, TSH, and anti-TPO antibody was performed. Pregnancy outcome was recorded.
Results: There were 25 cases of subclinical hypothyroidism in first trimester and 20 in second trimester. 8 cases of Hypothyroxinemia in first and 7 in second trimester. Overt hypothyroid was seen in 10 in first and 6 in second trimester. There were 5 cases in first and 4 cases in second of euthyroid. The mean parity was 1.2, 1.7, 1.1 and 1.0 in subclinical hypothyroidism, hypothyroxinemia, overt hypothyroid and euthyroid respectively. The mean BMI (Kg/m2) was 24.3, 27.8, 26.8 and 24.1. There were current smokersie. 4, 3, 1 and 5 and prior pregnancy was seen in 5, 4, 2 and 1 in subclinical hypothyroidism, hypothyroxinemia, overt hypothyroid and euthyroid respectively. Maximum cases of miscarriage (2) were seen in subclinical hypothyroidism and gestational hypertension (5) in overt hypothyroidism. Pre- eclampsia (1) was seen in subclinical and overt hypothyroid, pre- term PROM (3) hypothyroxinemia, pre- term labor (2) in subclinical hypothyroidism and 5 cases of gestational diabetes mellitus was seen in hypothyroxinemia.
Conclusion: Overt hypothyroidism in pregnancy is detrimental to the developing fetal brain. Pregnancy outcome showed cases of miscarriage, pre- eclampsia, pre- term PROM, pre- term labor and GDM.
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