European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Dengue virus infection has emerged as a notable public health problem in recent decades . Laboratory evaluation of  dengue  Serological markers and  platelet count help in early diagnosis and can be used as predictor to reduce the morbidity and mortality of dengue disease.
Aim: Aim of  this  study is  to evaluate  Dengue  serological  markers for early diagnosis of cases  and to study  the correlation between  serological markers  and  platelet count  in dengue positive cases .
Materials and Methods: This was a cross-sectional prospective study  conducted  in  the Tertiary  health care centre , Hyderabad..  All clinically suspected cases of dengue, reported  to various outpatient departments, emergency services and admitted patients in the Hospital were included for this study,  from  July to   September   2018 . The Chi-Square test and statistical software Epi info and MS excel was used to find out the statistical significance of the estimate.
Results:   Among  700 blood  samples were  received from clinically suspected case of dengue , 125 (17.85%)  cases  were detected dengue positive  out of which  65 (52%) cases showed platelet count less than 1 lakh. . In confirmed dengue cases, thrombocytopenia is more consistently found in  dengue  positive cases  with only IgM  and only NS1 positive cases compared to other serological groups.
Conclusion: Detection of  dengue specific serological markers along with platelet count  in the diagnosis of dengue, increases the early diagnosis so as to avoid complications significantly and can be used as prognostic marker to reduce the morbidity and moratlity of dengue disease.