• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 9, Issue 2
  3. Author

Online ISSN: 2515-8260

Volume9, Issue2

A comparative study to evaluate the efficacy of dexmedetomidine with normal saline in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation

    Dr. Ashwini GS, Dr. Ranjith Kumar RT, Dr. Megha GH, Dr. Dharuni Priya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2415-2420

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Introduction: Laryngoscopy and endotracheal intubation often provoke an undesirable increase in arterial blood pressure and/or heart rate1,2,3. Alpha 2-adrenergic agonists like dexmedetomidine have been extensively used to suppress the hemodynamic response to laryngoscopy and endotracheal intubation.
Methods: The study was conducted among 60 ASA grade I and II patients between 18-60 years of age, scheduled for elective surgeries under general anaesthesia. The study population was subdivided randomly into 2 groups each consisting 30 patients. Group D received Dexmedetomidine 0.5mcg/kg IV diluted to 10 ml with normal saline. Group S received Normal saline 10 ml IV.
Results: There was a significant fall in HR in group D at 5 and 10 minutes after drug administration. The mean HR increase observed at 1, 3, 5 and 10 minutes after intubation in group NS was statistically significant. The mean SBP values at 5 and 10 minutes after drug administration were significantly low in group D. The increase in SBP in group NS at 1, 3, 5 and 10 minutes after intubation was statistically significant. The mean DBP values at 5 and 10 minutes after drug administration were significantly low in group D. The increase in DBP in group NS at 1, 3, 5 and 10 minutes after intubation was statistically significant. There was a significant difference in MAP values at 5 and 10 minutes after drug administration which was statistically significant. The increase in MAP in group NS was statistically significant at 1, 3, 5 and 10 minutes after intubation.
Conclusion: We conclude that Dexmedetomidine 0.5 μg/kg before laryngoscopy and endotracheal intubation effectively attenuates the hemodynamic response as compared to normal saline without major adverse effects.
Keywords:
    Dexmedetomidine laryngoscopy endotracheal intubation sympathoadrenal response
  • PDF (542 K)
  • XML
(2022). A comparative study to evaluate the efficacy of dexmedetomidine with normal saline in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation. European Journal of Molecular & Clinical Medicine, 9(2), 2415-2420.
Dr. Ashwini GS, Dr. Ranjith Kumar RT, Dr. Megha GH, Dr. Dharuni Priya. "A comparative study to evaluate the efficacy of dexmedetomidine with normal saline in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation". European Journal of Molecular & Clinical Medicine, 9, 2, 2022, 2415-2420.
(2022). 'A comparative study to evaluate the efficacy of dexmedetomidine with normal saline in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation', European Journal of Molecular & Clinical Medicine, 9(2), pp. 2415-2420.
A comparative study to evaluate the efficacy of dexmedetomidine with normal saline in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation. European Journal of Molecular & Clinical Medicine, 2022; 9(2): 2415-2420.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 36
  • PDF Download: 50
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus