A Hospital Based Prospective Study To Compare The Efficacy Of Drotaverine Hydrochloride And Valethamate Bromide On Cervical Dilation In Active Labour At Newly Established Tertiary Care Centre
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 12082-12088
AbstractBackground: Labour is a natural physiological phenomenon of childbirth. Painless and short labor is desired by every woman and is a constant aim for obstetrician. To avoid prolonged labour and its ill effects, sedation, amniotomy, oxytocin and prostaglandin have been used. The aim of this study to compare the efficacy of drotaverine hydrochloride and valethamate bromide on cervical dilation in active labour at newly established tertiary care centre.
Materials& Methods: This prospective study was conducted in Govt. Hospital for maternal & child health care at the Institute of Obstetrics and Gynaecology attached to Government Medical College, Dungarpur, Rajasthan, India during one year period. The patients were divided into 3 groups of 50 patients. Group I (Normal labour patients) (N=50), Group II (Patients who received Inj. Drotaverine Hydrochloride) (N=50) and Group III (Patients who received Inj. Valethamate Bromide) (N=50). Various parameters of duration of labor, mode of delivery, maternal and fetal complications and side effects of these drugs were compared in three groups.
Results: Drotaverine hydrochlomide and Valethamate bromide achieved 53% and 38% reduction in mean duration of active phase of labour respectively compared with control group. The mean rate of cervical dilatation was 2.66 cm/hrfaster with Drotaverine and 1.50 cm/hr with epidosin compared to control. The mean drug delivery interval was 47.72% shortened by Drotaverine and 35.90% shortened by Valethamate compared to Active phase Delivery interval of Controlgroup.
Conclusion: Drotaverine hydrochloride is a superior cervical dilatation agent significantly reducing the duration of labour without any ill effects on the motheror the fetus. It is significantly better than Valethamate bromide with less side effects due to selective action. Hence it is recommended that Drotaverine Hydrochloride may be given to low-risk women in active labour.
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