Evaluation of cardiac biomarkers in predicting severity of dengue fever
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 2, Pages 2508-2513
AbstractDengue virus will affect several systems of the body. Myocardial involvement may be the direct effect of the virus itself or may be due to cytokine production. Myocarditis has a varied presentation, it may be clinical or subclinical. Myocarditis can present as cardiac failure, Electrocardiogram (ECG) changes (sinus bradycardia, sinus tachycardia, T wave inversion), 2 D Echocardiography changes (reduced ejection fraction) and elevated cardiac enzymes (Troponin T, CPK, CPK-MB, LDH, N terminal-BNP). The study was approved by the institutional ethical committee. Informed written consent was obtained from the parents of each patient before enrollment. History and examination findings were recorded in a pre-structured proforma. Children with clinically diagnosed dengue fever (WHO criteria) & serologically confirmed and admitted cases between the age group of 2months to 18 years formed the study group. In 110 biomarker positive cases, 32(17.3%) had a shock, 14 (7.6%) had bleeding manifestations, 78(42.2%) cases had elevated SGOT and SGPT and PT and aPTT elevated in 84(45.4%) and 44(23.8%) cases respectively.
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