European Journal of Molecular & Clinical Medicine

Abstract

Dengue virus will affect several systems of the body. Myocardial involvement may be the direct effect of the virus itself or may be due to cytokine production. Myocarditis has a varied presentation, it may be clinical or subclinical. Myocarditis can present as cardiac failure, Electrocardiogram (ECG) changes (sinus bradycardia, sinus tachycardia, T wave inversion), 2 D Echocardiography changes (reduced ejection fraction) and elevated cardiac enzymes (Troponin T, CPK, CPK-MB, LDH, N terminal-BNP). The study was approved by the institutional ethical committee. Informed written consent was obtained from the parents of each patient before enrollment. History and examination findings were recorded in a pre-structured proforma. Children with clinically diagnosed dengue fever (WHO criteria) & serologically confirmed and admitted cases between the age group of 2months to 18 years formed the study group. In 110 biomarker positive cases, 32(17.3%) had a shock, 14 (7.6%) had bleeding manifestations, 78(42.2%) cases had elevated SGOT and SGPT and PT and aPTT elevated in 84(45.4%) and 44(23.8%) cases respectively.