A Study on Histopathological Changes in Spectrum of Gallbladder Diseases
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 1970-1975
AbstractIntroduction: Gallstones are the commonest biliary pathology, the incidence ranging from 10% to 20% of the world population. Over 95% of biliary tract disease is attributable to cholelithiasis. Gallbladder stones are known to produce histopathological changes in the gallbladder.
Aim: To study spectrum of gallbladder diseases in cholecystectomy specimens and the incidence of various neoplastic and non neoplastic lesions occurring in gallbladder
Materials and Methods: All clinical details and data from case sheet and patient history are collected and analysed in Department of Pathology, Prasad Institute of Medical Sciences, Lucknow From( June 21 to June 22) grossly examined and routinely processed and stained with H&E stain. Three sections each from neck, body and fundus taken. Tissues were processed in automated tissue processor and paraffin blocks made. Statistical analysis of the data was done.
Results: Total number of specimens received were 72 and among the cases the number of females were 66 and the number of males were 6. Out of 72 cases of cholecystectomy the number of cases of calculous cholecystitis was 62 (86%) and the number of cases of acalculous cholecystitis was 10 (14%) Majority of cases of cholecystectomy were found to be with gallstones (Calculous cholecystitis) and only a few cases were found to be without gallstones (Acalculous cholecystitis).
Conclusions: Almost all of the gallbladder lesions are inflammatory in origin, of which the most common disease being chronic cholecystitis in female of 30–40 years presenting with abdominal pain. Thirdly, pigmented gall stones were found to be the most common etiology of chronic cholecystitis and malignancy of the gallbladder in this population is a rare occurrence.
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